What is nuclear medicine ?RadiopharmaceuticalsNuclear medicine : Radiopharmaceuticals are radioactive compounds administered to the patient, and monitored via specific imaging devices, for diagnosis and therapeutic purposes. by Philippe van Put, IRE Elite
Radioisotopes emitting penetrating gamma rays are used for diagnostic (imaging) where the radiation has to escape the body before being detected by a specific device (SPECT/PET cameras). Typically, the radiation emitted by isotope used for imaging vanishes completely after 1 day through radioactive decay and normal body excretion. The most common isotopes for imaging are: 99mTc, I-123, I-131, Tl201, In111 and F18. Radioisotopes emitting short range particles (alpha or beta) are used for therapy due to their power to lose all their energy over a very short distance, therefore causing a lot of local damage (such as cell destruction). This property is used for therapeutic purposes: cancer cells destruction, pain treatment in palliative care for bone cancer or arthritis. Such isotopes stay longer in the body than imaging ones; this is intentional in order to increase treatment efficiency, but this remains limited to several days. The most common therapeutic isotopes are: I131, Y90, Rh188 and Lu177.
Before being accessible for routine clinical use, the radiopharmaceutical has to demonstrate its harmlessness for the patient and its benefit for the treatment, like any classical drug. This demonstration process is strictly regulated by the Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) in Europe. The typical duration for such a process is typically 5 to 8 years, from the initial discovery to the availability for the physicians.  |